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Manufacutured by:  Organon  (homepage)
Shipping:                   Packaged and Distributed from China


Product Information
Same formulation as in Desogen (product summary)
Detailed Information (Data Sheet)


Description

Uses
This is an estrogen and progestin combination pill used for the prevention of pregnancy. It works by preventing ovulation (the release of an egg from an ovary) and pregnancy. It may also be taken to regulate the menstrual cycle.  Your doctor may choose to use this medication for other conditions. If you're unsure why you are taking this medication, contact your doctor.

Contents
21 tablets containing 0.15mg desogestrel and 0.03mg ethinylestradiol


Dosage and Administration
The first tablet is taken on the first day of menstruation. This also applies when changing over from another brand of oral contraceptive. One tablet is taken daily at the same time, without interruption for 21 days, followed by a 7-day tablet-free period. Each subsequent pack is started after the 7-day tablet-free period has elapsed.

Contraindications
This medication should not be taken by anyone who is pregnant or has or has had any of the following, thrombophlebitis or thromboembolic disorders, cerebrovascular disorders (e.g., stroke), a heart attack, coronary artery disease, active liver disease, benign or malignant liver tumors, breast cancer, a tumour reliant on estrogen, undiagnosed abnormal vaginal bleeding, any eye lesion resulting from vascular disease of the eye.

Interactions
Some medicines may reduce the effectiveness of oral contraceptives.  Irregular bleedings and reduced reliability may occur when oral contraceptives are used concomitantly with medicines such as anti-convulsants, barbiturates, antibiotics (e.g. tetracyclines, rifampicin, etc.), activated charcoal and certain laxatives.  The requirements for oral antidiabetics or insulin can change.  


Warnings and Precautions

Before starting on Marvelon, a thorough general medical (including blood pressure measurement, urine test for sugar and, if necessary, special liver tests) and gynaecological (including breasts and cytological smear) examination must be conducted to detect any diseases requiring treatment or risks. The family case history should be carefully noted. Disturbances of the clotting system must be ruled out if any members of the family have suffered from thromboembolic diseases (e.g. deep vein thrombosis, stroke, myocardial infarction) already at a young age. Pregnancy must be excluded.

Gastro-intestinal upset
Vomiting and diarrhoea may reduce efficacy by preventing full absorption. Barriers and spermicides should be used until 7 days after the upset; (mild laxatives do not impair contraceptive action).

Adverse Effects
Nausea, vomiting, abdominal cramps, breakthrough bleeding, breast changes, changes in menstrual flow, changes in cervical erosion and cervical secretions, amenorrhoea during and after treatment, anovulation post treatment, cholestatic jaundice, pruritus, allergic rash, photosensitivity, poor tolerance of contact lenses, alopecia, chloasma, erythema multiforme, erythema nodosum, haemorrhagic eruption, hirsuitism, headache, depressive moods, migraine, dizziness, drowsiness, changes in appetite, body weight and libido can occur.

The physician should be alert to the earliest manifestations of thrombotic disorders and medication should be discontinued immediately should any of these occur.  If there is a sudden, partial or complete loss of vision or if there is a sudden onset of proptosis, diplopia or migraine, medication should be discontinued and examination made. If examination reveals papilloedema or retinal vascular lesions the medication should be discontinued.  Further reasons for immediate discontinuation are immobilisation (e.g. following accidents), onset of jaundice, onset of anicteric hepatitis, itching of the whole body, increase in epileptic seizures, significant rise in blood pressure, pregnancy. Oral contraceptive medication should be discontinued at least six weeks prior to elective surgery because of the danger of thrombosis.  According to the present state of knowledge, an association between the use of progestogen-oestrogen combinations and an increased risk of venous and arterial thromboembolic diseases cannot be ruled out. 

The risk of thrombotic and cardiac effects from oral contraceptives increases with age and is aggravated by cigarette smoking.

Under the influence of oral contraceptives pre-existing uterine fibroids may increase in size.  Patients with conditions such as cardiac or renal dysfunction, diabetes or a tendency to diabetes, high blood pressure, varicose veins, a history of phlebitis, otosclerosis, multiple sclerosis, epilepsy, migraine, porphyria, tetany or chorea minor require careful observation whilst on oral contraceptive therapy.  Patients with a history of depression should be carefully observed and the medication discontinued if serious depression recurs.  A decrease in glucose tolerance occurs in a significant number of patients on oral contraceptives.  Susceptible women may experience a rise in blood pressure during therapy.